Research article2011Peer reviewedOpen access
The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion
Miller, C.; Wang, Liya; Östergaard, E. et al.
Liya Wang
Department of Animal Biosciences
Faculty of Veterinary Medicine and Animal Sciences
Email: Liya.Wang@slu.se
Publications
2011
2010
Research article2010Peer reviewedOpen access
Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae
Wang, Liya; Hames, Claudine; Schmidl, Sebastian R. et al.
Research article2010Peer reviewed
Tissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion
Wang, Liya; Eriksson, Staffan.
Research article2010Peer reviewed
Identification and Characterization of Mitochondrial Factors Modulating Thymidine Kinase 2 Activity
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Research article2010Peer reviewed
Deoxynucleoside Salvage Enzymes and Tissue Specific Mitochondrial DNA Depletion
Wang, Liya.
Research article2010Peer reviewed
Thymidylate synthases of Mycoplasma mycoides subsp mycoides SC and Ureaplasma parvum are flavin-dependent
Wehelie, Rahma; Eriksson, Staffan; Bölske, G et al.
Research article2010Peer reviewedOpen access
3 '-(1,2,3-Triazol-1-yl)-3 '-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations
Lin, Jay; Roy, V; Wang, Liya et al.
Research article2010Peer reviewed
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1
Welin M, Egeblad Louise, Johansson A, Stenmark P, Wang Liya, Flodin S, Nyman T, Tresaugues L, Kotenyova T, Johansson I, Eriksson Staffan, Eklund Hans, Nordlund P.
2008
Research article2008Peer reviewed
5-bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts
Wang, Liya; Eriksson, Staffan.
Research article2008Peer reviewed
Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism
Eriksson, Staffan; Wang, Liya.
Research article2008Peer reviewedOpen access
Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase
Carnrot, Cecilia; Wang, Liya; Topalis, Dimitri et al.
2007
Research article2007Peer reviewed
Structure-function analysis of a bacterial deoxyadenosine kinase reveals the basis for substrate specificity
Welin M, Wang LY, Eriksson S, Eklund H.
Research article2007Peer reviewedOpen access
Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding
Kosinska U, Carnrot C, Sandrini MPB, Clausen AR, Wang LY, Piskur J, Eriksson S, Eklund H.
Research article2007Peer reviewedOpen access
Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance - Transgenic TK2, mtDNA, and antiretrovirals
Hosseini SH, Kohler JJ, Haase CP, Tioleco N, Stuart T, Keebaugh E, Ludaway T, Russ R, Green E, Long R, Wang LY, Eriksson S, Lewis W.
Research article2007Peer reviewed
The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates
Wang, LY.
Research article2007Peer reviewedOpen access
Structural and functional investigations of Ureaplasma parvum UMP kinase - a potential antibacterial drug target
Egeblad-Welin L, Welin M, Wang L, Eriksson S.
2006
Research article2006Peer reviewed
Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs
Carnrot C, Vogel SR, Byun Y, Wang LY, Tjarks W, Eriksson S, Phipps AJ.
Research article2006Peer reviewed
Kinetic mechanism of deoxyadenosine kinase from Mycoplasma determined by surface plasmon resonance technology
Pol E, Wang LY.
2005
Research article2005Peer reviewed
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes
Wang LY, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S.
Research article2005Peer reviewedOpen access
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus
Ren H, Wang LY, Bennett M, Liang YH, Zheng XF, Lu F, Li LF, Nan J, Luo M, Eriksson S, Zhang CM, Su XD.
Research article2005Peer reviewed
Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme
Kosinska U, Carnrot C, Eriksson S, Wang L, Eklund H.
2004
Research article2004Peer reviewed
Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum
Wehelie, Rahma; Eriksson, Staffan; Wang, Liya.
Research article2004Peer reviewedOpen access
Structures of thymidine kinase 1 of human and mycoplasmic origin
Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu CY, Wang LY, Eriksson S, Munch-Petersen B, Eklund H.
2003
Research article2003Peer reviewed
Comparison of cytotoxicity of 2-chloro-2 '-arabino-fluoro-2 '-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia
Lindemalm S, Liliemark J, Gruber A, Eriksson S, Karlsson MO, Wang YY, Albertioni F.
Research article2003Peer reviewed
Mitochondrial deoxyguanosine kinase mutations and mitochondrial DNA depletion syndrome
Wang, LY; Eriksson, S.
Research article2003Peer reviewed
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth
Carnrot, C; Wehelie, R; Eriksson, S et al.
Research article2003Peer reviewedOpen access
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy
Wang LY, Saada A, Eriksson S.
2001
Research article2001Peer reviewedOpen access
Antiviral Guanosine Analogs as Substrates for Deoxyguanosine Kinase: Implications for Chemotherapy
Herrström Sjöberg, Anita; Wang, Liya; Eriksson, Staffan.
Research article2001Peer reviewedOpen access
Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides
Wang, Liya; Westberg, Joakim; Bölske, Göran et al.
2000
Research article2000Peer reviewedOpen access
Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria
Wang, Liya; Eriksson, Staffan.
1999
Research article1999Peer reviewedOpen access
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
Wang, Liya; Munch-Petersen, Birgitte; Herrström Sjöberg, Anita et al.
Research article1999Peer reviewedOpen access
Cloning and characterization of mouse deoxyguanosine kinase : Evidence for a cytoplasmic isoform
Petrakis, Thodoris G.; Ktistaki, Eleni; Wang, Liya et al.
1998
Research article1998Peer reviewed
Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs
Herrström Sjöberg, Anita; Wang, Liya; Eriksson, Staffan.
1997
Doctoral thesis1997Open access
Mitochondrial deoxyribonucleoside salvage enzymes : cloning and characterization of deoxyguanosine kinase and thymidine kinase
Wang, Liya.
Research article1997Peer reviewed
Substrate Specificities, Expression and Primary Sequences of Deoxynucleoside Kinases; Implications for Chemotherapy
Eriksson, Staffan; Wang, Liya.
1996
Research article1996Peer reviewedOpen access
Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA
Eriksson, Staffan; Hellman, Ulf; Wang, Liya.
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